Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation
نویسندگان
چکیده
منابع مشابه
The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation
Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimer's disease (AD). Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase. Inhibiting β-secretase activity is believed to be one of the most promising strategies for AD treatment. In the present study, we fo...
متن کاملAlzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.
β-Amyloid protein (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from proteolytic cleavages of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. BACE1 is the rate-limiting enzyme for Aβ production, and an increase in BACE1 level/activity contributes to the pathogenesis of sporadic AD. In addition to cl...
متن کاملAmyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†
BACE1 cleaves the amyloid precursor protein (APP) at the β-cleavage site (Met(671) -Asp(672) ) to initiate the generation of amyloid peptide Aβ. BACE1 is also known to cleave APP at a much less well-characterized β'-cleavage site (Tyr(681) -Glu(682) ). We describe here the identification of a novel APP mutation E682K located at this β'-site in an early onset Alzheimer's disease (AD) case. Funct...
متن کاملSynaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn, Robert S. Sloviter, Kelly R. Bales, Patrick C. May, Darryle D. Schoepp, Steven M. Paul, Steven Mennerick, and David M. Holtzman* Department of Neurology Department of Psychiatry Department of Anatomy and Neurobiology Department of Molecular Biology and Pharmacology The Hope Center for Neurological Disorders Washington University School of Medic...
متن کاملNeuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant
β-Secretase, BACE1 is a neuron-specific membrane-associated protease that cleaves amyloid precursor protein (APP) to generate β-amyloid protein (Aβ). BACE1 is partially localized in lipid rafts. We investigated whether lipid raft localization of BACE1 affects Aβ production in neurons using a palmitoylation-deficient mutant and further analyzed the relationship between palmitoylation of BACE1 an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.532713